Impact of medical care, including use of anti-infective agents, on prognosis of COVID-19 hospitalized patients over time.
Identifieur interne : 000D32 ( Main/Exploration ); précédent : 000D31; suivant : 000D33Impact of medical care, including use of anti-infective agents, on prognosis of COVID-19 hospitalized patients over time.
Auteurs : Benjamin Davido [France] ; Ghilas Boussaid [France] ; Isabelle Vaugier [France] ; Thibaud Lansaman [France] ; Frédérique Bouchand [France] ; Christine Lawrence [France] ; Jean-Claude Alvarez [France] ; Pierre Moine [France] ; Véronique Perronne [France] ; Frédéric Barbot [France] ; Azzam Saleh-Mghir [France] ; Christian Perronne [France] ; Djillali Annane [France] ; Pierre De Truchis [France]Source :
- International journal of antimicrobial agents [ 1872-7913 ] ; 2020.
Abstract
INTRODUCTION
The effect of anti-infective agents in COVID-19 is unclear. The impact of changes in practice on prognosis over time has not been evaluated.
METHODS
Single center, retrospective study in adults hospitalized in a medicine ward for COVID-19 from March 5
RESULTS
A total of 132 patients were admitted: mean age 59.0±16.3 years; mean C-reactive protein (CRP) level 84.0±71.1 mg/L; 46% had a lymphocyte count <1000/mm
CONCLUSION
The present study showed a significant decrease in admission to ICU over time, which was probably related to multiple factors, including a better indication of pulmonary CT-scan, oxygen therapy, and a suitable prescription of anti-infective agents.
DOI: 10.1016/j.ijantimicag.2020.106129
PubMed: 32755653
PubMed Central: PMC7396133
Affiliations:
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wicri:level="1"><nlm:affiliation>Réanimation médicale, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Réanimation médicale, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Perronne, Veronique" sort="Perronne, Veronique" uniqKey="Perronne V" first="Véronique" last="Perronne">Véronique Perronne</name><affiliation wicri:level="1"><nlm:affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Barbot, Frederic" sort="Barbot, Frederic" uniqKey="Barbot F" first="Frédéric" last="Barbot">Frédéric Barbot</name><affiliation wicri:level="1"><nlm:affiliation>Centre d'Investigation Clinique (Inserm CIC 1429), Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Investigation Clinique (Inserm CIC 1429), Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Saleh Mghir, Azzam" sort="Saleh Mghir, Azzam" uniqKey="Saleh Mghir A" first="Azzam" last="Saleh-Mghir">Azzam Saleh-Mghir</name><affiliation wicri:level="1"><nlm:affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Perronne, Christian" sort="Perronne, Christian" uniqKey="Perronne C" first="Christian" last="Perronne">Christian Perronne</name><affiliation wicri:level="1"><nlm:affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" 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uniqKey="Davido B" first="Benjamin" last="Davido">Benjamin Davido</name><affiliation wicri:level="1"><nlm:affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France. Electronic address: benjamin.davido@aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Boussaid, Ghilas" sort="Boussaid, Ghilas" uniqKey="Boussaid G" first="Ghilas" last="Boussaid">Ghilas Boussaid</name><affiliation wicri:level="3"><nlm:affiliation>Université Paris-Saclay, UVSQ, Erphan, 78000, Versailles, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Saclay, UVSQ, Erphan, 78000, Versailles</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Versailles</settlement></placeName></affiliation></author><author><name sortKey="Vaugier, Isabelle" sort="Vaugier, Isabelle" uniqKey="Vaugier I" first="Isabelle" last="Vaugier">Isabelle Vaugier</name><affiliation wicri:level="1"><nlm:affiliation>Centre d'Investigation Clinique (Inserm CIC 1429), Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Investigation Clinique (Inserm CIC 1429), Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Lansaman, Thibaud" sort="Lansaman, Thibaud" uniqKey="Lansaman T" first="Thibaud" last="Lansaman">Thibaud Lansaman</name><affiliation wicri:level="1"><nlm:affiliation>Rééducation fonctionnelle, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Rééducation fonctionnelle, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Bouchand, Frederique" sort="Bouchand, Frederique" uniqKey="Bouchand F" first="Frédérique" last="Bouchand">Frédérique Bouchand</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacie Hospitalière, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmacie Hospitalière, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Lawrence, Christine" sort="Lawrence, Christine" uniqKey="Lawrence C" first="Christine" last="Lawrence">Christine Lawrence</name><affiliation wicri:level="1"><nlm:affiliation>EOH, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>EOH, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Alvarez, Jean Claude" sort="Alvarez, Jean Claude" uniqKey="Alvarez J" first="Jean-Claude" last="Alvarez">Jean-Claude Alvarez</name><affiliation wicri:level="1"><nlm:affiliation>Pharmaco-toxicologie, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Pharmaco-toxicologie, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Moine, Pierre" sort="Moine, Pierre" uniqKey="Moine P" first="Pierre" last="Moine">Pierre Moine</name><affiliation wicri:level="1"><nlm:affiliation>Réanimation médicale, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Réanimation médicale, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Perronne, Veronique" sort="Perronne, Veronique" uniqKey="Perronne V" first="Véronique" last="Perronne">Véronique Perronne</name><affiliation wicri:level="1"><nlm:affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Barbot, Frederic" sort="Barbot, Frederic" uniqKey="Barbot F" first="Frédéric" last="Barbot">Frédéric Barbot</name><affiliation wicri:level="1"><nlm:affiliation>Centre d'Investigation Clinique (Inserm CIC 1429), Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Investigation Clinique (Inserm CIC 1429), Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Saleh Mghir, Azzam" sort="Saleh Mghir, Azzam" uniqKey="Saleh Mghir A" first="Azzam" last="Saleh-Mghir">Azzam Saleh-Mghir</name><affiliation wicri:level="1"><nlm:affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Perronne, Christian" sort="Perronne, Christian" uniqKey="Perronne C" first="Christian" last="Perronne">Christian Perronne</name><affiliation wicri:level="1"><nlm:affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><affiliation wicri:level="1"><nlm:affiliation>Réanimation médicale, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Réanimation médicale, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author><author><name sortKey="De Truchis, Pierre" sort="De Truchis, Pierre" uniqKey="De Truchis P" first="Pierre" last="De Truchis">Pierre De Truchis</name><affiliation wicri:level="1"><nlm:affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches</wicri:regionArea><wicri:noRegion>Garches</wicri:noRegion><wicri:noRegion>Garches</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of antimicrobial agents</title><idno type="eISSN">1872-7913</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>The effect of anti-infective agents in COVID-19 is unclear. The impact of changes in practice on prognosis over time has not been evaluated.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Single center, retrospective study in adults hospitalized in a medicine ward for COVID-19 from March 5</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>A total of 132 patients were admitted: mean age 59.0±16.3 years; mean C-reactive protein (CRP) level 84.0±71.1 mg/L; 46% had a lymphocyte count <1000/mm</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The present study showed a significant decrease in admission to ICU over time, which was probably related to multiple factors, including a better indication of pulmonary CT-scan, oxygen therapy, and a suitable prescription of anti-infective agents.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32755653</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7913</ISSN><JournalIssue CitedMedium="Internet"><Volume>56</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Oct</Month></PubDate></JournalIssue><Title>International journal of antimicrobial agents</Title><ISOAbbreviation>Int. J. Antimicrob. Agents</ISOAbbreviation></Journal><ArticleTitle>Impact of medical care, including use of anti-infective agents, on prognosis of COVID-19 hospitalized patients over time.</ArticleTitle><Pagination><MedlinePgn>106129</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0924-8579(20)30312-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijantimicag.2020.106129</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The effect of anti-infective agents in COVID-19 is unclear. The impact of changes in practice on prognosis over time has not been evaluated.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Single center, retrospective study in adults hospitalized in a medicine ward for COVID-19 from March 5<sup>th</sup> to April 25<sup>th</sup> 2020. Patient characteristics were compared between two periods (before/after March 19<sup>th</sup>) considering French guidelines. The aim of the study was to evaluate how medical care impacted unfavorable outcome, namely admission to intensive care unit (ICU) and/or death.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 132 patients were admitted: mean age 59.0±16.3 years; mean C-reactive protein (CRP) level 84.0±71.1 mg/L; 46% had a lymphocyte count <1000/mm<sup>3</sup>. Prescribed anti-infective agents were lopinavir-ritonavir (n=12), azithromycin (AZI) (n=28) and AZI combined with hydroxychloroquine (HCQ) (n=52). There was a significant decrease in ICU admission, from 43% to 12%, between the two periods (P<0.0001). Delays until transfer to ICU were similar between periods (P=0.86). Pulmonary computerized tomography (CT)-scans were performed significantly more often with time (from 50% to 90%, P<0.0001), and oxygen-dependency (53% vs 80%, P=0.001) and prescription of AZI±HCQ (from 25% to 76%, P<0.0001) were also greater over time. Multivariate analyses showed a reduction of unfavorable outcome in patients receiving AZI±HCQ (hazard ratio [HR]=0.45, 95% confidence interval [CI: 0.21-0.97], P=0.04), particularly among an identified category of individuals (lymphocyte ≥1000/mm<sup>3</sup> or CRP ≥100 mg/L).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The present study showed a significant decrease in admission to ICU over time, which was probably related to multiple factors, including a better indication of pulmonary CT-scan, oxygen therapy, and a suitable prescription of anti-infective agents.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Davido</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France. Electronic address: benjamin.davido@aphp.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boussaid</LastName><ForeName>Ghilas</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Université Paris-Saclay, UVSQ, Erphan, 78000, Versailles, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vaugier</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre d'Investigation Clinique (Inserm CIC 1429), Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lansaman</LastName><ForeName>Thibaud</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Rééducation fonctionnelle, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouchand</LastName><ForeName>Frédérique</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Pharmacie Hospitalière, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawrence</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>EOH, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alvarez</LastName><ForeName>Jean-Claude</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Pharmaco-toxicologie, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moine</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Réanimation médicale, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perronne</LastName><ForeName>Véronique</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barbot</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Centre d'Investigation Clinique (Inserm CIC 1429), Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saleh-Mghir</LastName><ForeName>Azzam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perronne</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Annane</LastName><ForeName>Djillali</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Réanimation médicale, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Truchis</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Maladies Infectieuses, Université Paris-Saclay, AP-HP Hôpital Raymond Poincaré, Garches, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>COVID-19 RPC Team</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Int J Antimicrob Agents</MedlineTA><NlmUniqueID>9111860</NlmUniqueID><ISSNLinking>0924-8579</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Covid-19</Keyword><Keyword MajorTopicYN="N">azithromycin</Keyword><Keyword MajorTopicYN="N">hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">pneumonia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>07</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>07</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32755653</ArticleId><ArticleId IdType="pii">S0924-8579(20)30312-5</ArticleId><ArticleId IdType="doi">10.1016/j.ijantimicag.2020.106129</ArticleId><ArticleId IdType="pmc">PMC7396133</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Versailles</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Davido, Benjamin" sort="Davido, Benjamin" uniqKey="Davido B" first="Benjamin" last="Davido">Benjamin Davido</name></noRegion><name sortKey="Alvarez, Jean Claude" sort="Alvarez, Jean Claude" uniqKey="Alvarez J" first="Jean-Claude" last="Alvarez">Jean-Claude Alvarez</name><name sortKey="Annane, Djillali" sort="Annane, Djillali" uniqKey="Annane D" first="Djillali" last="Annane">Djillali Annane</name><name sortKey="Barbot, Frederic" sort="Barbot, Frederic" uniqKey="Barbot F" first="Frédéric" last="Barbot">Frédéric Barbot</name><name sortKey="Bouchand, Frederique" sort="Bouchand, Frederique" uniqKey="Bouchand F" first="Frédérique" last="Bouchand">Frédérique Bouchand</name><name sortKey="Boussaid, Ghilas" sort="Boussaid, Ghilas" uniqKey="Boussaid G" first="Ghilas" last="Boussaid">Ghilas Boussaid</name><name sortKey="De Truchis, Pierre" sort="De Truchis, Pierre" uniqKey="De Truchis P" first="Pierre" last="De Truchis">Pierre De Truchis</name><name sortKey="Lansaman, Thibaud" sort="Lansaman, Thibaud" uniqKey="Lansaman T" first="Thibaud" last="Lansaman">Thibaud Lansaman</name><name sortKey="Lawrence, Christine" sort="Lawrence, Christine" uniqKey="Lawrence C" first="Christine" last="Lawrence">Christine Lawrence</name><name sortKey="Moine, Pierre" sort="Moine, Pierre" uniqKey="Moine P" first="Pierre" last="Moine">Pierre Moine</name><name sortKey="Perronne, Christian" sort="Perronne, Christian" uniqKey="Perronne C" first="Christian" last="Perronne">Christian Perronne</name><name sortKey="Perronne, Veronique" sort="Perronne, Veronique" uniqKey="Perronne V" first="Véronique" last="Perronne">Véronique Perronne</name><name sortKey="Saleh Mghir, Azzam" sort="Saleh Mghir, Azzam" uniqKey="Saleh Mghir A" first="Azzam" last="Saleh-Mghir">Azzam Saleh-Mghir</name><name sortKey="Vaugier, Isabelle" sort="Vaugier, Isabelle" uniqKey="Vaugier I" first="Isabelle" last="Vaugier">Isabelle Vaugier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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